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KMID : 1004820130140030170
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Journal of Biomedical Research
2013 Volume.14 No. 3 p.170 ~ p.176
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Effects of probiotic CS-32 as a feed additive on growth performance of broiler chickens
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Kim Se-Eun
Choi Ga-Hoi
Shim Kyung-Mi
Kim Jong-Choon
Yoo Jin-Cheol
Cho Seung-Sik
Kang Seong-Soo
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Abstract
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In the livestock feed industry, antibiotics are used to prevent disease, promote growth rate, and improvefeed efficiency. However, antibiotic supplementationto animal feed results in increased bacterial resistanceto antibiotics as well as antibiotic residues in animalproducts, which can negatively affect human health.Therefore, alternative sources of antibiotics are needed.Probiotics as an alternative to antibiotics in animalfeed have been shown to increase feed efficiency andgrowth rate by improving microbial balance. Further,Bacillus sp. produces a wide spectrum of antibacterialpeptides. The present study was conducted toinvestigate the effects of dietary supplementationwith CS-32 on safety, growth rate, and feed efficiency.Antibacterial substance (5697.9 molecular weights)produced by CS-32 was isolated and purified fromculture broth. Moreover, the results of minimal inhibitoryconcentration (MIC) test confirmed the excellentantibacterial effect of CS-32. In vivo, 0.1% and 1%CS-32 were fed to broiler chickens for 28 days. Feedefficiency was slightly higher in groups of chickenssupplemented with 0.1% and 1% CS-32 than those ofthe control group. CS-32 had no significant effect onnecropsy findings, hematology, or serum biochemistry,and there was no mortality. These results suggest thatCS-32 among various biologically active substancesmay be safe and effective as a feed additive to improvegrowth rate and feed efficiency.
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KEYWORD
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feed additive, probiotic, CS-32, antibacterial effect, chicken
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